Mucin: Why should you care?

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Mucin: Why should you care?  

Mucin is a major component of intestinal mucus layer. The ability to utilize mucin offers an ecological benefit to these bacteria over those that are dependent on dietary nutrients, providing a source of host-derived nutrients while the geographical location provides a means of interacting with the immune system.

Science can explain why we should care about our Mucin.

A. muciniphila is inversely proportional to body weight and type-1 diabetes.27,33 A. muciniphila is specialized as it colonizes the mucus lining and can use mucin as a sole carbon and nitrogen source, releasing growth substrates for other beneficial bacteria.34,35 Interestingly, in a recent study, Roseburia hominis and Roseburia intestinalis have also been found to utilize mucin as energy source indicating that mucin degradation is more widespread than was previously appreciated.36  37 Notably, Christensenella minuta and Oscillospira spp. have also been linked with a lean phenotype and may be useful targets when combating obesity.11,24,28 The establishment of potential relationships such as these support the continued efforts in identifying approaches to encourage the growth of target microbes in the gut.



Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression – PubMed (

MUC5 and MUC6 represent major secretory mucins in the stomach and are localized to distinct cell types.

Mucin gene structure and expression: protection vs. adhesion – PubMed (

Respiratory tract mucin genes and mucin glycoproteins in health and disease – PubMed (

Mucin genes and the proteins they encode: structure, diversity, and regulation – PubMed (

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